GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs9322193 | 1 | rs58189451 | chr6:149921388 | C6orf72 | chr6:149887528-149912067:+ | -0.19 | -5.17 | 3.46E-7 | Lung cancer |
| THCA | cis | rs9322193 | 1 | rs58189451 | chr6:149921388 | NUP43 | chr6:150045453-150067688:- | -0.26 | -4.56 | 6.51E-6 | Lung cancer |
| THCA | cis | rs9322193 | 1 | rs58189451 | chr6:149921388 | RAET1E | chr6:150204512-150217195:- | 0.22 | 4.86 | 1.61E-6 | Lung cancer |
| THCA | cis | rs9322193 | 1 | rs58189451 | chr6:149921388 | RAET1K | chr6:150319157-150326280:- | -0.22 | -3.46 | 0.000581 | Lung cancer |
| THCA | cis | rs72627123 | 1 | rs58204112 | chr14:74359417 | LIN52 | chr14:74551656-74667117:+ | 0.24 | 4.54 | 7.28E-6 | Morning vs. evening chronotype |
| THCA | cis | rs72627123 | 1 | rs58204112 | chr14:74359417 | PTGR2 | chr14:74318534-74352166:+ | 0.22 | 3.56 | 0.000415 | Morning vs. evening chronotype |
| THCA | cis | rs72627123 | 1 | rs58204112 | chr14:74359417 | ZNF410 | chr14:74318674-74398803:+ | 0.24 | 4 | 7.31E-5 | Morning vs. evening chronotype |
| THCA | cis | rs7107174 | 1 | rs58235466 | chr11:78030886 | NARS2 | chr11:78147017-78285909:- | -0.4 | -7.65 | 1.08E-13 | Testicular germ cell tumor |
| THCA | cis | rs10518128 | 1 | rs58242818 | chr4:75699164 | BTC | chr4:75671448-75719882:- | 0.21 | 3.92 | 0.000102 | Electroencephalogram traits |
| THCA | cis | rs1552244 | 1 | rs58275763 | chr3:10143274 | C3orf10 | chr3:10157333-10168873:+ | -0.21 | -4.38 | 1.45E-5 | Alzheimer's disease |
| THCA | cis | rs1552244 | 1 | rs58275763 | chr3:10143274 | VHL | chr3:10183319-10193744:+ | -0.19 | -4.25 | 2.55E-5 | Alzheimer's disease |
| THCA | cis | rs2129782 | 1 | rs58289747 | chr8:89414691 | MMP16 | chr8:89049462-89339717:- | 0.31 | 4.94 | 1.08E-6 | Electrodermal activity |
| THCA | cis | rs3745672 | 1 | rs58336952 | chr19:12057916 | ZNF763 | chr19:12035900-12091196:+ | -0.4 | -4.82 | 1.91E-6 | Multiple sclerosis |
| THCA | cis | rs2129782 | 1 | rs58337229 | chr8:89390073 | MMP16 | chr8:89049462-89339717:- | 0.32 | 4.95 | 1.04E-6 | Electrodermal activity |
| THCA | cis | rs1000940 | 1 | rs58351927 | chr17:5297038 | C1QBP | chr17:5336099-5342471:- | 0.15 | 4.29 | 2.14E-5 | Body mass index |